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Point of care and AI-driven early detection of Alzheimer’s, through a simple eye exam.

1. Eye Examination

Our AI-based solution analyses data-rich images captured with existing retinal imaging cameras available in most eye clinics — this means that the experience is familiar and comfortable.

2. Data-Rich Images

Data-rich images of the retina are captured using high resolution retinal imaging providing the basis for detailed analysis and more accurate results. Each pixel has over 100 colors instead of just 3 (i.e., red, green, blue) in a regular color image. 

3. Explainable AI (XAI)

Automated Alzheimer’s detection uses artificial intelligence to help clinicians detect Alzheimer’s years before the emergence of clinical symptoms, with future possibilities of AI algorithms to assist clinicians in identifying other diseases.

Publications

Small Title

Dec, 2023

Hyperspectral analysis of amyloid beta (Aβ) evolutional changes in preclinical to late-stage Alzheimer’s disease using matched brain and retinal tissue

M. Flanagan, B. Danner, C. Zamudio, C. Spencer, J. N. Lilek, A. Matos, M. Morris, K. Ajroud, W. Xie, C. Bornbaum, J.  Westreich, S. More

Oct, 2023

Implementing cognitive assessment and RetiSpec retinal screening in community-based settings: enhancing early detection of Alzheimer’s disease

S. Cohen, A. Kurzman, J. Giordano, R. Naureen, A. Hansen, M. Martinez, M. Bietenhader, N. Sohbati, N. Abdulla, C. Cameron, S. Estreicher, S. Semwel, C. Bornbaum

Small Title

Oct, 2023

RetiSpec’s AI-based retinal test: Results of a multi-site, prospective, validation study to predict brain Aβ pathology in a diverse population of adults with preclinical, mci, and probable Alzheimer’s disease. 

A. Hazan, C. Bornbaum, E. Shaked, J. Giordano, Y. Edlitz, D. He, D. Kerwin

Small Title

Nov, 2019

In Vivo Assessment of Retinal Biomarkers by Hyperspectral Imaging: Early Detection of Alzheimer's Disease

S. More, J.M. Beach, C. McClelland, A. Mokhtarzadeh, R. Vince

Small Title

Jun, 2016

Early Detection of Amyloidopathy in Alzheimer's Mice by Hyperspectral Endoscopy

S. More; J.M. Beach, R. Vince

Small Title

Oct, 2014

Hyperspectral Imaging Signatures Detect Amyloidopathy in Alzheimer’s Mouse Retina Well before Onset of Cognitive Decline; ACS Chem.

S. More, R. Vince

Recent Conference Presentations

Small Title

Screening for Memory Concerns in Optometry Settings to Facilitate Early Detection of Alzheimer’s Disease:Measuring the Utility of the RetiSpec Scan

N. Sohbati, N. Abdulla, M. Bietenhader, J. Giordano, C. Bornbaum, S. Cohen

RetiSpec’s AI-based retinal test: Results of a multi-site, prospective, validation study to predict brain AB pathology in a diverse population of adults with Preclinical, MCI, and Probable Alzheimer’s disease

A. Hazan, C. Bornbaum, E. Shaked, J. Giordano, Y. Edlitz, D. He, D. Kerwin

Small Title

Hyperspectral analysis of amyloid beta (Aβ) evolutional changes in preclinical to late-stage Alzheimer’s disease using matched brain and retinal tissue

M. Flanagan, B. Danner, C. Zamudio, C. Spencer, J.N. Lilek, A. Matos, M. Morris, K. Ajroud, W. Xie, C. Bornbaum, J. Westreich,  S. More

Small Title

 Screening for memory concerns in community-based settings to facilitate early detection of Alzheimer's disease: Can optometry clinics serve as a useful venue?

S. Cohen, J. Giordano, A. Hansen, M. Martinez, N. Sohbati, M. Bietenhader, C. Bornbaum

Small Title

 Implementing cognitive assessment and RetiSpec retinal screening in community based settings: Enhancing early detection of Alzheimer's disease

S. Cohen, A. Kurzman, J. Giordano, R. Naureen, A. Hansen, M. Martinez, M. Bietenhader, N. Sohbati, N. Abdulla, C. Cameron, S. Estreicher, S. Semwel, C. Bornbaum

Small Title

 Clinical and Postmortem Analysis of Retinal Tissue

B. Danner, C.. Zamudio, C Spencer, J. Lilek, A. Matos, M. Morris, K. Ajroud, M.E. Flanagan

Small Title

RetiSpec's Hyperspectral Imaging System: Results of a Validation Study in Preclinical AD and MCI

S. Cohen, A. Plante, A. Hazan, A. Gribble, Y.P.  Lin, J. DiGregorio, J. Westreich, I. Cohen, A. Strilchuk, J. Soehner, F. Leblond, M. Schnaider-Beeri

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